|
Diabetes Mellitus
|
0.700 |
GeneticVariation
|
group |
BEFREE |
While it appeared that common genetic traits characterize diabetes regardless of the subtype (1a or 1b), certain features differentiate the two forms of IDDM.
|
8988536 |
1996 |
|
Diabetes Mellitus
|
0.700 |
AlteredExpression
|
group |
BEFREE |
When we perturbed signalling by expressing dominant-negative forms of the receptors, FGFR1c and FGFR2b, in the pancreas, we found that that mice with attenuated FGFR1c signalling, but not those with reduced FGFR2b signalling, develop diabetes with age and exhibit a decreased number of beta-cells, impaired expression of glucose transporter 2 and increased proinsulin content in beta-cells owing to impaired expression of prohormone convertases 1/3 and 2.
|
11130726 |
2000 |
|
Diabetes Mellitus
|
0.700 |
AlteredExpression
|
group |
BEFREE |
We therefore analyzed fasting proinsulin levels in 99 siblings of insulin-dependent diabetes mellitus (IDDM) patients, most of them discordant for diabetes for greater than 6 yr.
|
2792577 |
1989 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
We studied plasma renin, prorenin, and four polymorphic markers of the renin gene in 199 patients with IDDM and DN, and in 192 normoalbuminuric IDDM controls matched for age, sex, and duration of diabetes.
|
10462269 |
1999 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
We show that CE prevent insulin-deficient diabetes in male and in female Akita mice using a model of misfolded proinsulin.
|
29972779 |
2018 |
|
Diabetes Mellitus
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We sequenced KCNJ11, ABCC8 and insulin (INS) genes in 33 unrelated Indian probands with onset of diabetes below one year of age.
|
22831748 |
2013 |
|
Diabetes Mellitus
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We screened the INS gene by direct sequencing in 38 PND patients and in one child with nonautoimmune early-infancy diabetes, where no mutation in GCK, KCNJ11, and ABCC8 was identified.
|
18171712 |
2008 |
|
Diabetes Mellitus
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We reproduced the association of diabetes-associated variants with proinsulin/insulin ratios, and also examined the association of a TCF7L2 haplotype with obesity in the Framingham Heart Study (FHS).
|
19183934 |
2009 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
We previously reported the development of an oral vaccine for diabetes based on live attenuated Salmonella-expressing preproinsulin (PPI) as the autoantigen.
|
30416020 |
2018 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
We observed a significantly higher annual incidence (per 100,000/year) of IDDM in female subjects (1.81), older age-groups (2.25 for 8-14 years), subjects with no family history of diabetes (1.26), diabetes onset in the spring (2.20), and an increased trend over the 20 years.
|
9773722 |
1998 |
|
Diabetes Mellitus
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We identified one missense mutation (G32S) in the INS gene and two mutations (R131Q and R203S) in the HNF1α gene that could be associated with diabetes.
|
27398945 |
2016 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
We identified differentially expressed miRNAs in limbus vs. central cornea in normal and diabetic (DM) corneas including both type 1 (T1DM/IDDM) and type 2 (T2DM/NIDDM) diabetes.
|
28615632 |
2017 |
|
Diabetes Mellitus
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We hope to emphasize instead the homogeneity of nephropathy risk in both IDDM and NIDDM and also the idea that a common genetic susceptibility exists for all types of diabetes and is conditional on cumulative exposure to hyperglycemia.
|
9649955 |
1998 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
We have previously shown that the introduction of furin-cleavable human insulin (INS-FUR) to the livers in several animal models of diabetes resulted in the reversal of diabetes and partial pancreatic transdifferentiation of liver cells.
|
29578255 |
2018 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
We genotyped the 5'INS VNTR locus and several flanking 11p15.5 markers in 50 Finnish APECED subjects and explored the possible contribution of IDDM2 in the development of diabetes.
|
20535137 |
2010 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
We describe the durable correction of streptozotocin-induced murine diabetes by in vivo implantation of primary mouse hepatocytes electroporated ex vivo with a human proinsulin cDNA plasmid construct controlled by glucose and zinc regulatory elements.
|
15703765 |
2005 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
We conclude that the Proinsulin Kyoto gene is not a common cause of DM and the occurrence of the alpha type insulin gene in Japanese diabetes is more frequent than in other races, so this Pst I polymorphism is not a marker for diabetes mellitus in Japanese.
|
7951555 |
1994 |
|
Diabetes Mellitus
|
0.700 |
AlteredExpression
|
group |
BEFREE |
We conclude that increased fasting proinsulin levels precede abnormalities of insulin secretion, and are an early indication of minor B-cell damage in these twins irrespective of their risk of developing diabetes.
|
3286344 |
1988 |
|
Diabetes Mellitus
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Variability in the number of tandem repeats of the insulin gene (INS-VNTR) is known to associate with PCOS, and it is associated with an increased risk of diabetes mellitus and other cardiovascular diseases.
|
22468791 |
2012 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
True insulin and proinsulin were measured during a 75-g OGTT in 35 individuals: 20 with normal glucose tolerance (NGT) and without diabetes among their first-degree relatives (FDR) served as controls, and 15 with NGT who were FDR of patients with NIDDM.
|
10347771 |
1999 |
|
Diabetes Mellitus
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice.
|
8971078 |
1997 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
Tolerizing vaccination of NOD mice with a cDNA plasmid expressing full-length proinsulin prevented diabetes, whereas plasmids encoding ZnT8 and DβH did not.
|
27069933 |
2016 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
Together, the results demonstrate that the INS-PLLA PMs have a strong potential as an effective strategy for inhalation treatment of diabetes.
|
30284409 |
2019 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
To investigate whether recombinant human insulin-like growth factor-I (rhIGF-I) has direct effects on the insulin requirement to maintain euglycemia independent of the growth hormone (GH) level, nine subjects with insulin-dependent diabetes mellitus ([IDDM] seven females; median (range) age, duration of diabetes, and hemoglobin A1C [HbA1C], 16.9 (12.5 to 21.9) years, 11.8 (4.6 to 16.8) years, and 9.8% (7.9% to 14.1%), respectively) underwent two euglycemic studies (6:00 PM to 8:00 AM) after double-blind subcutaneous administration of rhIGF-I/placebo (40 microg/kg).
|
9440474 |
1998 |
|
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
To determine whether apo(a) isoforms and plasma Lp(a) concentrations in association with some lipid parameters increase the relative risk for the development of atherosclerosis in patients with diabetes mellitus (IDDM and NIDDM).
|
14563448 |
2003 |